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Standard: CP2005, BP2000, BP2005, USP28, USP29,
Packing: 25KG/ kraft paper Bag, 14MT/20FCL; 25KG/Fibre drum, 9MT/20FCL
CAS No.: 87-78-5
Molecular formula: C6H14O6
Molecular Weight: 182.178
Characteristics:
Mannitol is colorless crystalline powder, odor free and with sweet taste, it is easily dissolve in water and slightly dissolve in ethyl alcohol.
Applications:
Injection material: Used in producing the mannitol injection solution, reducing the encephalic pressure, the intraocular pressure etc.
Excipient of filler for tablets:
Used in the anticancer drug, antibacterial, antihistamine medicine, in vitamin, drunk awaking drug, the mouth freshener tablet and so on. Vasodilator medicine for blood vessel for brain: Used in treating the blood vessel blocked of brain.
Diuretic stuff:
Mannitol is a kind of mild laxative lapactic, which has a special curative effect to oliguria and the kidney function failure caused by dropsy, burnt and so on.
| Item | CP2000 | BP 2000 | USP24 |
| Appearance | White crystalline powder; odorless, sweet taste | White crystalline powder, soluble in water, slightly soluble in ethanol, non-soluble in aether | White crystalline powder, soluble in water, slightly soluble in ethanol, non-soluble in aether |
| Melting point | 166 ~ 170 | 165 ~ 170 | 164 ~ 169 |
| Identification | Pass on test | Pass on test | Pass on test |
| Acidity or Basicity | ≤0.3ml of 0.02mol/L NaOH | ≤0.3ml of 0.01mol/L HCL or≤0.2ml of 0.01mol/L NaOH | ≤0.3ml of 0.02mol/L NaOH |
| Clarity and color of Solution | Clear and colorless | Clear and colorless | |
| Chloride % | ≤0.003 | ≤0.005 | ≤0.007 |
| Sulphate % | ≤0.010 | ≤0.010 | ≤0.01 |
| Oxalate % | ≤0.020 | ||
| Residue on ignition % | ≤0.1 | ≤0.1 | |
| Loss on drying % | ≤0.5 | ≤0.5 | ≤0.3 |
| Arsenic % | ≤0.0002 | ≤0.0001 | |
| Heavy metals % | ≤0.001 | ≤0. 00005 | |
| Nickle % | ≤0.0001 | ||
| Specific optical rotation | +23°+25°(in borax solution) | +137°+145° (in ammonium molybdate solution) | |
| Reducing sugars | No more than few deposit | ||
| Assay % | 98.0 ~ 102.0 | 98.0 ~ 101.5 | 96.0 ~ 101.5 |
| Sorbitol % | ≤2 | ||
| Bacterial endotoxin | <100g/l of mannitol,≤4 I.U./g≥100g/l of mannitol,≤2.5 I.U./g |
